Opioid Induced Rhabdomyolysis with Acute Sensorimotor Axonal Neuropathy: An Unusual Presentation

Main Article Content

Suraj Agrawal
Navneet Sharma
Sanjay Jain
Ritu Attri
Mandip Singh Bhatia


Rhabdomyolysis is a clinical condition of potentially life threatening destruction of skeletal muscles caused by diverse mechanisms including drug and toxins. Opioid is one of the encountered drug which cause rhabdomyolysis in association with renal failure. Paraparesis is one of the important feature of rhabdomyolysis which usually occur due to dyselectrolytemia (secondary hyperkalemic periodic paralysis) recovers completely on normalization of electrolyte, we are presenting a case of opioid induced rhabdomyolysis who develop paraparesis even with normal electrolyte which later on diagnosed as acute sensory motor axonal neuropathy.

Dyselectrolytemia, rhabdomyolysis, axonal neuropathy, muscle injury.

Article Details

How to Cite
Agrawal, S., Sharma, N., Jain, S., Attri, R., & Bhatia, M. S. (2020). Opioid Induced Rhabdomyolysis with Acute Sensorimotor Axonal Neuropathy: An Unusual Presentation. Asian Journal of Case Reports in Medicine and Health, 2(4), 1-3. Retrieved from https://www.journalajcrmh.com/index.php/AJCRMH/article/view/30113
Case Report


Prendergast BD, George CF. Drug induced rhabdomyolysis mechanism and management. Postgrad Med J. 1993; 69:333-336.

Huerta-Alardin AL, Varon J, Marik PE. Bench-to bedside review: rhabdomyolysis – An overview for clinicians. Crit Care. 2005;9:158-169.

Melli G, Chaudhry V, Cornblath DR. Rhabdomyolosis: an evaluation of 475 hospitalized patients. Medicine (Baltimore). 2005;84:377-385.

Warren JD, Blumberg PC, Thompson PD. Rhabdomyolysis: A review. Muscle Nerve. 2002;25: 332-347.

Goldfarb DS, Chung S. The absence of rhabdomyolysis induced renal failure following the world trade center collapse. Am J Med. 2002;113:260.

Deighan Cj, Wong KM, McLaughlin KJ, Harden P. Rhabdomyolysis and acute renal failure resulting from alchohal and drug abuse. QJM. 2000;93:29-33.

Mousavi SR, Taghaddosinejad F, Talae H, Zare GA, Sadeghi M, Rajaee P, et al. Clinical and laboratory evaluation of Rhabdomyolysisin 165 patients with severe acute poisonings. J Birjand Uni Mad Scie. 2010;17:136-142(Persian).

Talaie H, Pajouhmand A, Abdollahi M, Panahandeh R, Emami H, Hajinasrolah S, et al. Rhabdomyolysis among acute human poisoning cases. Hum Exp Toxicol. 2007;26:557-561.

Gabow PA, Kaehny WD, Kelleher SP. The Spectrum of Rhabdomyolysis. Medicine (Baltimore). 1982;61:141-152.

Taheri SK, Afzali S, Torabian S. Rhabdomyolysis Syndrome in alcohol, p;sychotropic drugs and illicit substance poisonings. Iran J Toxicol. 2013;7:866-870.

Kuhlman GD, Gwathmey KG. Gluteal compartment syndrome with neurological impairment: Report of 2 cases and review of literature. Muscle Nerve. 2018;57:325-330.